Anti-inflammatory Function of Gut Macrophages

Anti-inflammatory Function of Gut Macrophages Colonic mucosa is a very peculiar immunological site daily exposed to a huge amount of harmless antigens. It is important for the immune system to be able to recognize this innocuous antigens from pathogens. Among all the immune cells, CX3CR1+ macrophages exploit this critical role. In this commentary on our recent publication on Immunobiology (Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages(1)we want to highlight the crucial and unique role of these macrophages in order to maintain homeostasis and avoid the rise of aberrant inflammation and tissue damage. The intestine is an exclusive tissue able to maintain balance between the immune system activation and the tolerance against the very huge amount of harmless antigens that are in contact with the intestinal lumen, including food antigens and microflora. It is fundamental for our health that our immune system is able to respond with a robust and appropriate response to potential dangerous antigens; but the same reaction against harmless antigens, like commensal bacteria or dietary proteins, could be very dangerous and could give rise to allergies or chronic inflammation that, in the end, can lead to tissue damage or cancer development. Many immune cells participate to the maintenance of the homeostasis in gut, with the role of understanding how an antigen is a potential danger for the organism and being silenced in response to commensal bacteria and food antigens. This complex landscape includes T and B lymphocytes, natural killer cells, innate lymphoid cells, eosinophils and mononuclear phagocytes: dendritic cells and macrophages. Among the latter, monocyte-derived macrophages, expressing the CX3CR1 receptor, constitute the most abundant population (2). The manuscript by Marelli et al., is focused on the role of CX3CR1+ macrophages in both steady state and acute colitis. In the last few years intensive research has been performed in order to clarify the role of these immune cells in the maintenance of homeostasis, but still, contrasting results have been reported regarding their role in the control of inflammatory response in the intestine (3,4). Considering this confused landscape, our paper aimed to clarify the role of CX3CR1+ cells in the development of acute colitis. By using mice lacking the receptor (CX3CR1GFP/GFP mice) we demonstrated that the absence of CX3CR1 on gut macrophages leads to a more severe degree of DSS-induced colitis, higher colon infiltration of inflammatory macrophages and Th17 lymphocytes and higher expression of inflammatory cytokines. Macrophages in the intestinal mucosa are considered mononuclear phagocytes that originate from a common myeloid progenitor which can differentiate also into dendritic cells (5). In contrast to others resident macrophages, they are continuously replenished from blood stream Ly6C+ monocytes, independently from the CX3CR1 receptor (6). This issue caused considerable misunderstanding in the past, generating the belief that these cells were dendritic cells (7,8). However, today it is recognized that Ly6Chi monocytes are recruited in the mucosa and there, in few days, they differentiate in mature macrophages, progressively loosing Ly6C and starting to express typical markers, such as F4/80, CD64, MHCII and CX3CR1 (6). As highlighted before, different authors investigated the role of CX3CR1+ gut macrophages with controversial outcomes. CX3CR1+ macrophages are supposed to maintain homeostasis in the gut (9). In accordance with this concept, our data revealed an exacerbated intestinal inflammation with a huge accumulation of macrophages in CX3CR1-KO mice. As reported also by different authors, (3,10) the natural consequence of the accumulation of macrophages is an increased production of cytokines, and hence a higher recruitment of immune cells in the colon, in particular T lymphocytes of the Th17 subset. On the contrary, other authors (4) suggested that the lack of the receptor impairs macrophages accumulation in the lamina propria. Moreover they suggested that the engagement of the receptor by its unique ligand (Fracktalkine/CX3CL1) resulted in an intensification of iNOS production, an inflammatory enzyme. Our data, instead, clearly demonstrate that the absence of the receptor increases the level of iNOS and of many other pro-inflammatory cytokines. This is a tissue-specific competence of the intestine, being colon ic resident macrophages an exemption from the rules. Indeed, in other tissues, the expression of CX3CR1 receptor is associated with a pro-inflammatory phenotype (11,12). In support of our data it is important to underline that, in the gut, CX3CR1 macrophages are fundamental to bring antigens and present them to DC in order to establish oral tolerance. When this mechanism is missing due to the lack of the receptor, the immune system is activated and this results in an acute inflammatory response (8). We have shown in Marelli et al. that if the CX3CR1 receptor is lacking, the ability of these cells to control inflammation is lost. Of note, CX3CR1-KO macrophages try counter-balance this aberrant situation by producing more IL-10, a major immune-suppressive and anti-inflammatory cytokine. In spite of this increase, IL-10 is not sufficient to control the inflammatory disease and mice have an exacerbated colitis. Overall, with our study we wanted to propose a definitive protective and anti-inflammatory role of CX3CR1+ macrophages during the processes of acute colitis; this concept may shed light also on the role of these cells in other pathological conditions of the gut associated with persistent inflammation. Our study established that macrophages expressing the functional CX3CR1 receptor have a non-redundant role in the control of aberrant intestinal inflammation, a harmful condition that may lead to tissue injury. CX3CR1 receptor expressed on intestinal macrophages is able to control colitis, avoiding the rise of aberrant inflammation. When the receptor is missing, the balance in the gut is broken, leading these cells to produce a huge amount of cytokines. Feeling the higher level of inflammation, CX3CR1 macrophages attempt to limit it by producing more IL-10, however this is not sufficient and the result is a higher accumulation of inflammatory Th17 lymphocytes and increased tissue injury.

How to Combat Inflation

Recommendations Based on the results generated from the multiple regression analysis of this research, there are few recommendations that can be implemented to combat the inflation in Malaysian economy. The recommendations are: 1. Malaysia government should focus on producing export goods than importing goods from other countries in order to encourage appreciation of Ringgit Malaysia currency value. In turn, it will decrease the inflation rate and trigger the purchasing power to other currencies namely, dollar, euro and pound. This is because countries with high inflation rate will experience depreciation in their currency.However, even though the ringgit appreciation can reduce the import prices, consumers may not able to get the benefit from the reduction. According to Central Bank, the vigorous appreciation of ringgit currency can slow down the export competitiveness that can directly impact income and weaken domestic demand. 2. GDP and CPI is directly impact each other. Income is adjusted according to the CPI level. In order to reduce the inflation rate, government should monitor the growth of GDP. If GDP is increase too fast, CPI also will increase too fast and subsequently, increase the cost of living.In addition, the government is slower than the market, making it almost impossible for government to keep up with the income adjustments needed to provide good quality of life to Malaysians. 3. It is Central Bank responsibility to decide the most appropriate deposit rate to be imposed on the money savers. One of the ways to reduce the inflation rate in Malaysia is by increasing the deposit rate so that people will save more and spends less. Increase in deposit rate can discourage borrowing, and somehow reduce the consumer spending and consequently reduce the inflation rate.

Income inequality Essay

It is the report which is talking about income inequality. It is global income inequality is increasing. Besides that that’s is more information about measurement for the income inequality The relationship between the income inequality and economic growth Technological change and globalisation partly on income inequality, Way to reduce the income inequality, Causes of income inequality, and High income inequality gap-Latin America. Mostly it is all about the income inequality in this assignment is telling about the income inequality. Income inequality Income inequality is about the measurement of people’s household or individual based on their income across the various participants in an economy. It is also known as the gap between the rich and poor, wealth and poverty, the different of income between populations or individual (Ram, R. (1988)). Measurement To measure the income inequality have to use the Gini coefficient which developed by Italian statistician in 1912. The Gini coefficient is measuring the income inequality based on the value of a frequency distribution (for example levels of income). The value of the Gini coefficient is between the range 0 to 1. Therefore, 0 that means â€Å"perfect equality ’’ which every person is getting the same income and 1 that means â€Å"perfect inequality’’ which is all income change to the share of the population with the highest income. The Gini coefficient is also to be used for to measure wealth inequality. This use of Gini coefficient requires that no one has a negative net wealth. Besides that, the Gini index often used which is the Gini coefficient expressed as a percentage, but it is equal to the Gini coefficient multiplied by 100. (Most of the time people are using the Gini index for calculating the income inequality. ) Graph1(source:http://people. stfx. ca) The graph above shows that the Gini coefficient is equal to the area which is shaded to the yellow colour. The relationship between the income inequality and economic growth Graph 2(source : author’s calculation) The graph above is showing the relationship between the income inequality and economic growth. Besides that, the graph above is showing the improvement in the Gini of 0. 01 costs 1. 6 per cent per year in per capita economic growth which mean economic growth improves may affect the income inequality. The relationships between the income inequality and economic growth have a very strong gap sometimes. That means change of economic growth would affect the income inequality. Therefore, the economic growth will reduce the income inequality when the salary of the lowest paid rise faster than the average wage. Besides that, the economic growth can increase the job opportunity for people to reduce the level of unemployment in the social. Economic growth often creates the job opportunity for those people who are high skilled and educated. After job opportunity increased can make the level of poverty decreased and reduce the income inequality. Enhancing the growth of economic may raise the income inequality such as increasing the flexibility of wage determination. The growth of economic is showing the extension for flexibility of wage determination. To increase the wage of employee may reduce the income inequality but it also made the labour cost increased for the employer. Increasing the wage agreement to firms may make some employers have to pay the highly salary of employee. This action may increase the unemployment and affected productivity of the company decreasing because labour cost too high makes the employer hard to endure (Murtin et al. , 2012). graph 3 The graph above is showing the global income inequality is increasing from the year 1820 to the year 2008. The Gini coefficient is increasing that mean income inequality is increasing at the same time. But, sometime the economic growth may not reduce the income inequality. It is because the Economic Growth will not necessarily solve unemployment. For example, growth cannot solve structural and frictional unemployment it is because unemployment (structural and frictional) which caused by lack of skills and geographical immobility. Technological change and globalisation partly on income inequality The current technology with globalisation might rise in the market equipment and create the boosting top incomes. (Rosen, 1981; Gordon and Dew-Becker, 2008). These days, the the change of technology is affecting too fast, however it can also influence the income inequality. It is due to inclined the job opportunity for people who high skilled, but also increasing the unemployment. For instance, those who have not high-skilled workers might drop their work due to the same repetitive happens that may be running on the technologies, technological for achieving the target. Thus the desires for those workers can decline due to the change of technological. Likewise, to estimate for both highly-skilled and low-skilled workers need to focus respective work even the technology change, both of them might difficult to replace by machines or lose their job. If the demand shift is not offset by the equal shift related to the labour supply, change in technology can lead to reduction in salary. (e. g. Autor et al. , 2006, Goos et al. , 2009). At the same time, the globalisation may also increase the income inequality. 1) The offshoring (change the national). It is talking about people from richer countries move to poorer countries or poorer country move to richer country. The offshoring happen because skill intensive in their country. For example, some people from the perspective of the skill-poor country may move to rich country for searching the job opportunity. For the conclusion, offshoring makes labour demand more skill intensive in both poorer and richer countries, thus it is increasing the income inequality in both groups of countries (Feenstra and Hanson, 1996). 2) Sometime, the firms are making a different in their profitability which can make the low-income workers work in satisfaction and create low-productivity firms. That would make the firm lose their competitor compare to the other company. At the same time, it may increase labour income inequality by lowering or reducing the employment (e. g. Egger and Kreickemeier,2009; Helpman et al. , 2010). Improvement of the Globalisation and technological change may further raise the income inequality. Besides that, technology may go to the globalisation but it is also increasing the competition between companies to the company in the world, that mean globalisation for technology may force firms to Innovate. Therefore, the Innovation is increasing the labour income inequality both temporarily – since R&D is skill intensive (Dinopoulos and Segerstrom, 1999; Neary, 2003) and it provided the R&D results in skill-biased on technological change as discussed above (Acemoglu, 2002). Caused of income inequality -Different religion, region, language and gender In Indian have many different of culture, race, religion and language. This situation is making the Indian citizen get a different education or maybe some of don’t even have the opportunity to study. It is because different of culture, race, religion language and sex in Indian might made some of them didn’t get the chance to study or educated. At the same, this kind of diversity is making a trouble to access to education and chance of employment might decrease also at the same time. This is calling the kind of discrimination. The different is making the people in suffer from significant of inequality in employment, education and income. This kind of situation is increasing because different family background might made the living standard become harder and difficult, caused the income increasing in India (Desai & Kulkarni, 2008). -Technology The technology is improving all the time, but it also is decreasing the opportunity of job for people who are unskilled and limited educated. The company have to increase productivity to satisfy the demand from market. A lot of companies are investing to the technology to increase their productivity and growth in their business. Therefore, the number of automatic machine increasing is decreasing the job for those people who are working in manual, handy, limited educated and unskilled. In the same time, the service job could increasing because the technology improvement and factory job such as manual and handy is reducing. The service increased but it is just a low pay job. Technology is increasing the income inequality and it is replaced many worker in factory in U. S (WSJ, Technology, Not Globalization,Feeds Income Inequality, July 24, 2008). -Education The raising of education level is the most efficient way to reduce the income inequality. It is because the education has the great relation to the income distribution. The investment in education can made the income inequality decreased and lowers the level of poverty. People who is educated can get a higher opportunity to get a job compared to those are limited educated. It is important to send the child to the school and educated for increasing their intelligence and knowledge for achieving their ambition. In Brazil have a high inequality of income because average of citizen of Brazil attends fewer year to school compared to other. Number of Brazilian is increasing compared to the other country compared to the Latin America (Carlos Aguiar de Medeiros of International Development Economics Associates, 2001) -Price Stability The price stability is also known as inflation problem. In Brazil, inflation happens is making the poor getting poorer but the rich getting richer. It is because when facing the inflation problem or price instability, the company (rich) is following the same contract of wage or income to pay the salary to their employee (poor). Therefore, the poor have to reduce their living standard with their unchanged pay or real lower wages. At the same time, the investor (rich) can move their financial to other country for more opportunity to protect their money during the inflation. But, the poorer citizens have to work in a harder situation so it is difficult for them to escape poverty. (Carlos Aguiar de Medeiros of International Development Economics Associates, 2001) -Impact of Social Benefits In China, government have to provide a lot of benefit to their citizen. For example of social benefit, it is more like social insurance income or pension benefit. Caused of population increased and economic reforms need a greater financial to stimulate the economic growth. Therefore, have to reduce the social benefit such as pension benefit. It is big impact those are affected and increasing the income inequality. At the same time, not only the pension benefits government of China have to reduce the other social benefits such house benefit, health benefits, food assistance and other when have to improve the economic growth but increase income inequality (Gao 2006). http://www. networkideas. org/ideasact/jun07/beijing_conference_07/carl_riskin. pdf Way to reduce income inequality -Immigration Immigration policy would make United States reduce the income inequality. To let in more immigrants who is highly educated and skill will making more job to the America workers. More immigrants don’t mean reduce the opportunity of job to the America workers because it is creating more jobs to those people who are limited educated and limited skill at the same time. While immigrants are highly educated came to America such as: doctor, engineers, lawyer, entrepreneurs and other may increasing the job opportunity to the citizen of America who is limited educated. The job for United State people could increase caused by the immigrants system. Therefore, reducing the number of workers (immigrants) who is limited education might reducing the income inequality to the America because created more opportunity for those people who is limited education and unskilled. (Enrico Moretti is the Michael Peevey and Donald Vial Chair in Labor Economics at the University of California, Berkeley. He is the author of â€Å"The New Geography of Jobs† (2012). ) -Education In the France that strategy been used make sure every citizen in the country might get the chance to study or educated. It is the one of way to reduce the income inequality which has to be start on education. The education is very important because it can the people in the country to improve their living standards; reduce the income inequality at the same time. New analysis is showing that an increasing for the job opportunity for people with education is associated which is making a decline in labour Earnings inequality in France (Fournier and Koske, 2012). An education is giving to every citizen for get a higher chance to get the job opportunity might reduce the income inequality. -Protecting Our Poor, Elderly and Women to Reduce Income Inequality In Singapore is making the new job for those women, elder worker, and poor people to find and obtain a new job. It is helping them to avoid poverty but have to reduce their salary in their new job. This kind of policy is enabling those workers such as migrants, women, and elder worker to get an income and escape poverty. In the labour market, giving the new job for those people might increase the productivity in Singapore and reduces the income inequality at the same time. But a new job in low pay is providing for that unemployment or can’t find the job; women have been terminated in their job because of pregnancy, and unconscionably obtuse of the elder employee. Have to pay in low wage because their productivity in work also reducing but it still can helped them to continue their live or living (SINGAPORE POPULATION WHITE PAPER, 2013) -Heavy-industry-oriented development strategy In China is starting the strategy of heavy-industry-oriented development to increase the speed of pace of industrialization. To focus of heavy-industry-oriented development strategy, China is increasing the amount of resource from the agriculture. At the same time, it is increasing the opportunity of job. It is because it is some kind of investment to increase the productivity of China by heavy-industry-oriented development which is providing by China government. To run the strategy, the government of China is moving the industry to the less developed rural regions for increasing the job opportunity for those people over there and reducing the income inequality. To reduce the region income inequality, the strategy of heavy-industry-oriented development might carry on rural region to increase their job opportunity. To increasing the growth of economic in China, have to increase the job opportunity for those are employment and increasing the productivity in China. This may decrease the income inequality gap in China (Yang 2002). Conclusion The information above is showing the income inequality is increasing in the world. The income inequality is making people become poorer for those are poor and make the people become richer for those are rich. Therefore it is the economic issue including the outcome, earning and economic growth. It is why income inequality is the one of target or problem for macroeconomic to solve. Reference -Ram, R. (1988) http://www. collinsdictionary. com/dictionary/english/income-inequality -Graph1 http://people. stfx. ca -Graph 2 (source : author’s calculation) -Murtin et al. , 2012 http://www. oecd. org/eco/labour/49421421. pdf

The Issues Of The Nursing Profession - 1693 Words

5/4/2016 The issues of the nursing profession have been inflating across the country, and require immediate solutions to stem this growing tide. Even though nursing has great benefits such as health insurance, great pay, and the fact that you get to help people, nursing has many issues. Some of the issues of the nursing profession include work place violence, short staffing and hazardous environments. Research shows that these issues have been inflating across the country, and require immediate solutions to stem this growing tide. Thesis Statement Even though nursing has great benefits such as health insurance, great pay, and the fact that you get to help people, nursing has many issues. Some of the issues of the nursing profession include work place violence, short staffing and hazardous environments. Research shows that these issues have been inflating across the country, and require immediate solutions to stem this growing tide. I. Work Place violence A. 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